Our Summary

The research paper is a systematic review of studies related to two surgical treatments for corneal scarring caused by a common virus known as Herpes Simplex Virus. The two treatments are Penetrating Keratoplasty (PK) and Deep Anterior Lamellar Keratoplasty (DALK). The researchers looked at 12 studies published between 2010 and 2019.

They found that both PK and DALK were equally effective in improving the patient’s vision. However, fewer complications were seen with DALK treatment, especially in less severe cases. The survival rates of the graft (transplanted tissue) were higher when the patients were given higher doses of a drug called acyclovir, along with topical steroids and antibiotic drops.

In simpler terms, if you have corneal scarring due to this virus, both treatments could improve your vision. But DALK might be a better choice as it has fewer complications and better chances of the transplanted tissue surviving, especially if you are also given higher doses of acyclovir and certain eye drops.

FAQs

  1. What are the two surgical treatments discussed in the research for corneal scarring caused by Herpes Simplex Virus?
  2. Between Penetrating Keratoplasty (PK) and Deep Anterior Lamellar Keratoplasty (DALK), which treatment has fewer complications and higher survival rates of the transplanted tissue?
  3. What role does the drug acyclovir play in the survival rates of the graft in corneal transplant treatments?

Doctor’s Tip

One helpful tip a doctor might tell a patient about corneal transplant is to follow all post-operative instructions carefully to ensure proper healing and successful outcomes. This may include taking prescribed medications, attending follow-up appointments, avoiding rubbing or touching the eyes, and protecting the eyes from injury or infection. By following these guidelines, patients can improve their chances of a successful recovery and optimal vision outcomes after a corneal transplant.

Suitable For

Patients with corneal scarring caused by Herpes Simplex Virus are typically recommended for corneal transplant, specifically Penetrating Keratoplasty (PK) or Deep Anterior Lamellar Keratoplasty (DALK). These surgical treatments are effective in improving vision in patients with corneal scarring, with DALK showing fewer complications and higher graft survival rates, especially in less severe cases. Additionally, patients who are given higher doses of acyclovir, along with topical steroids and antibiotic drops, have better outcomes following corneal transplant.

Timeline

Before corneal transplant:

  1. Patient experiences symptoms of corneal scarring such as blurry vision, sensitivity to light, and eye pain.
  2. Patient undergoes a thorough eye examination to determine the severity of the scarring and assess the need for a corneal transplant.
  3. Patient discusses treatment options with their ophthalmologist, including the choice between Penetrating Keratoplasty (PK) and Deep Anterior Lamellar Keratoplasty (DALK).
  4. Patient undergoes pre-operative tests and evaluations to ensure they are a suitable candidate for the surgery.

After corneal transplant:

  1. Patient undergoes the corneal transplant surgery, which involves removing the damaged corneal tissue and replacing it with a donor cornea.
  2. Patient is monitored closely in the immediate post-operative period for any complications or signs of rejection.
  3. Patient follows a strict post-operative care regimen, including taking prescribed medications and attending follow-up appointments with their ophthalmologist.
  4. Patient experiences gradual improvement in vision as the transplanted cornea heals and integrates with the surrounding tissue.
  5. Patient may need to make long-term lifestyle changes, such as avoiding certain activities that could put the transplanted cornea at risk.
  6. Patient continues to be monitored regularly by their ophthalmologist to ensure the long-term success of the corneal transplant.

What to Ask Your Doctor

Here are some questions a patient may consider asking their doctor about corneal transplant:

  1. What are the potential risks and complications associated with both Penetrating Keratoplasty (PK) and Deep Anterior Lamellar Keratoplasty (DALK)?
  2. How long is the recovery time for each type of corneal transplant procedure?
  3. Will I need to take any medications before or after the surgery, and if so, what are the potential side effects?
  4. What is the success rate of each procedure in improving my vision?
  5. How long can I expect the transplanted tissue to last?
  6. Are there any lifestyle changes or restrictions I should be aware of following the surgery?
  7. Will I need to follow up with a specialist or have regular check-ups after the surgery?
  8. What are the costs associated with each type of corneal transplant procedure, and will my insurance cover it?
  9. Are there any alternative treatment options I should consider before undergoing a corneal transplant?
  10. How experienced is the surgical team in performing corneal transplants, and what is their success rate with similar cases?

Reference

Authors: Skarentzos K, Chatzimichael E, Panagiotopoulou EK, Taliantzis S, Konstantinidis A, Labiris G. Journal: Acta Medica (Hradec Kralove). 2020;63(4):150-158. doi: 10.14712/18059694.2020.57. PMID: 33355075