Our Summary

This research paper is about how stem cells from human hair follicles could help in repairing Achilles tendon injuries in rabbits. The researchers first extracted these stem cells from human hair follicles and confirmed that they were indeed a type of stem cell that can develop into different types of cells, called mesenchymal stem cells. They then induced Achilles tendon injuries in rabbits and treated them with these stem cells. The results showed that the treated tendons were healthier, could withstand more load, and had higher levels of collagen (a protein that helps in tissue repair). The researchers also found that the treatment led to more collagen fiber regeneration, likely due to an increase in a molecule called Tenascin-C and a decrease in another molecule called matrix metalloproteinase-9. These findings suggest that stem cells from human hair follicles could be a promising treatment for Achilles tendon injuries.

FAQs

  1. How were the stem cells from human hair follicles used in the treatment of Achilles tendon injuries in rabbits?
  2. What improvements were observed in the Achilles tendons of rabbits after they were treated with stem cells from human hair follicles?
  3. What role do the molecules Tenascin-C and matrix metalloproteinase-9 play in the healing process of Achilles tendon injuries treated with stem cells from human hair follicles?

Doctor’s Tip

A doctor might tell a patient that following a proper rehabilitation program after tendon repair surgery is crucial for a successful recovery. This program typically includes physical therapy to help regain strength and flexibility in the affected area. It is important to follow the guidance of a medical professional and adhere to any prescribed exercises or activities to ensure the tendon heals properly and to prevent re-injury. Additionally, maintaining a healthy diet and staying hydrated can aid in the healing process. It is also important to avoid activities that may strain or put excessive pressure on the repaired tendon to allow it to fully heal.

Suitable For

Patients who are typically recommended tendon repair are those who have suffered from a tendon injury that has not healed properly on its own. This may include individuals with Achilles tendon injuries, rotator cuff tears, tennis elbow, or other tendon injuries that are causing pain, limited mobility, or instability. Tendon repair may also be recommended for athletes or individuals who rely on their tendons for daily activities and need to regain strength and function in the affected area. In some cases, surgery may be necessary to repair a severely damaged tendon, while in other cases, non-surgical treatments such as physical therapy or stem cell therapy may be recommended. Ultimately, the type of treatment recommended will depend on the severity of the injury and the individual patient’s needs and goals.

Timeline

  • Before tendon repair: The patient may have experienced an injury to the tendon, such as a tear or rupture, which can cause pain, swelling, and limited range of motion. They may have undergone imaging tests, such as an MRI, to determine the extent of the injury. The patient may have also tried conservative treatments, such as rest, physical therapy, and anti-inflammatory medications, without success.

  • During tendon repair: The patient undergoes surgery to repair the tendon, which may involve stitching the torn ends back together or using a graft to reinforce the tendon. The surgeon may also use stem cells or other biologic agents to promote healing and tissue regeneration. The patient will then undergo a period of rehabilitation, including physical therapy, to regain strength and mobility in the affected area.

  • After tendon repair: The patient will continue with physical therapy and rehabilitation to gradually increase the strength and flexibility of the repaired tendon. They may also need to modify their activities and follow a specific exercise program to prevent re-injury. Over time, the patient should experience a reduction in pain and an improvement in function, allowing them to return to their normal activities.

What to Ask Your Doctor

  1. What type of tendon injury do I have and how severe is it?
  2. What are the potential risks and benefits of tendon repair surgery?
  3. Are there non-surgical treatment options available for my tendon injury?
  4. How long is the recovery time following tendon repair surgery?
  5. What type of rehabilitation program will I need to follow after surgery?
  6. Are there any specific lifestyle changes I should make to promote healing after tendon repair surgery?
  7. How successful is tendon repair surgery in terms of long-term outcomes and preventing re-injury?
  8. Can stem cell therapy from human hair follicles be a viable treatment option for my tendon injury?
  9. What is the success rate of using stem cells from human hair follicles for tendon repair?
  10. Are there any potential side effects or complications associated with using stem cells from human hair follicles for tendon repair?

Reference

Authors: Ma Y, Lin Z, Chen X, Zhao X, Sun Y, Wang J, Mou X, Zou H, Chen J. Journal: Chin Med J (Engl). 2023 May 5;136(9):1089-1097. doi: 10.1097/CM9.0000000000002542. PMID: 37052142