Our Summary

This study involves creating a model of the human cornea using a special printing technology called digital light processing (DLP). This technology is known for being able to create detailed and complex structures, making it a good fit for the intricate nature of the human cornea. The “ink” used in this printing process is a special combination of substances that mimic the properties of the human cornea. The printed cornea models were clear, strong, and flexible enough to integrate with real corneal tissue. They also promoted growth and regeneration of corneal cells. This technology could be used to create corneal implants for people with corneal defects who are waiting for transplants.

FAQs

  1. What technology is used to create the model of the human cornea?
  2. What is the “ink” used in the printing process of the cornea model?
  3. How could this technology potentially benefit people with corneal defects?

Doctor’s Tip

A doctor might tell a patient considering a corneal transplant to follow post-operative care instructions carefully, including taking prescribed medications and attending all follow-up appointments. It is important to avoid rubbing or putting pressure on the eye, as well as avoiding activities that could potentially damage the new cornea. It is also important to protect the eye from injury and to wear protective eyewear as recommended by the doctor. Following these guidelines can help ensure a successful recovery and optimal outcome after a corneal transplant.

Suitable For

Patients who are typically recommended for corneal transplant include those with:

  1. Keratoconus: a condition where the cornea becomes thin and cone-shaped, leading to distorted vision.

  2. Corneal scarring from infections, injuries, or previous surgeries.

  3. Fuchs’ dystrophy: a condition where cells in the inner layer of the cornea deteriorate, leading to cloudy vision.

  4. Corneal ulcers that do not respond to medication.

  5. Corneal swelling (edema) that affects vision.

  6. Corneal degeneration or thinning (such as in cases of Pellucid Marginal Degeneration).

  7. Rejection of a previous corneal transplant.

Overall, patients who have significant vision loss or discomfort due to corneal conditions that cannot be corrected with glasses or contact lenses may be recommended for a corneal transplant.

Timeline

Before corneal transplant:

  1. Patient experiences symptoms of corneal disease or injury, such as blurred vision, sensitivity to light, pain, or redness.
  2. Patient undergoes a thorough eye examination and evaluation by an ophthalmologist to determine if a corneal transplant is necessary.
  3. Patient is placed on a waiting list for a suitable donor cornea, which can take several months to years depending on availability.
  4. Patient undergoes pre-operative testing and preparation for the transplant surgery.

After corneal transplant:

  1. Patient undergoes corneal transplant surgery, where the damaged or diseased cornea is replaced with a donor cornea.
  2. Patient is monitored closely in the immediate post-operative period for any signs of complications or rejection.
  3. Patient follows a strict post-operative care regimen, including taking medications to prevent rejection and infection, and attending regular follow-up appointments with the ophthalmologist.
  4. Patient experiences gradual improvement in vision and reduction of symptoms over time as the transplanted cornea heals and integrates with the surrounding tissue.
  5. Patient may need to wear glasses or contact lenses to achieve optimal vision after the transplant surgery.

What to Ask Your Doctor

  1. What is a corneal transplant and why is it necessary for my condition?
  2. What are the risks and potential complications associated with a corneal transplant?
  3. How long is the recovery process after a corneal transplant and what can I expect during this time?
  4. Are there any alternative treatments or procedures that could be considered instead of a corneal transplant?
  5. How successful are corneal transplants in general, and what is the likelihood of the transplant being successful in my specific case?
  6. What is the expected lifespan of a corneal transplant, and will I need any additional surgeries or treatments in the future?
  7. What are the steps involved in the corneal transplant procedure, and what should I do to prepare for it?
  8. How will the printed cornea model be used in my specific case, and what benefits does this technology offer compared to traditional corneal transplants?
  9. Are there any specific post-operative care instructions or medications that I will need to follow after the corneal transplant?
  10. How often will I need to follow up with you after the corneal transplant, and what signs or symptoms should I watch out for that may indicate a problem with the transplant?

Reference

Authors: Bhutani U, Dey N, Chowdhury SK, Waghmare N, Mahapatra RD, Selvakumar K, Chandru A, Bhowmick T, Agrawal P. Journal: Biomed Mater. 2024 Mar 21;19(3). doi: 10.1088/1748-605X/ad3312. PMID: 38471165