Our Summary

This research paper is about a study conducted to assess the effectiveness of a particular type of treatment for advanced cervical cancer. This treatment involves a combination of chemotherapy and radiotherapy, followed by a specific type of surgery called Type C1 nerve-sparing radical hysterectomy.

The study involved 25 patients with cervical cancer who were treated with the combination of chemotherapy and radiotherapy, and then underwent surgery. Of these, 20 patients had the surgery via a traditional open approach, while five had it done through a less invasive laparoscopic method.

The results showed that this treatment approach was successful in most cases. Almost 70% of the patients had no remaining disease after the treatment and surgery. However, 32% still had some residual disease. It was also found that none of the patients who had the surgery via the laparoscopic method had any bladder-related problems, while one of them had persistent vaginal discharge.

In conclusion, this study suggests that the combination of chemotherapy, radiotherapy, and Type C1 nerve-sparing radical hysterectomy can be an effective treatment for advanced cervical cancer. The surgical procedure, in particular, appears to be both practical and safe, with minimal side effects.

FAQs

  1. What is Type C 1 nerve-sparing radical hysterectomy?
  2. What were the results of the study on using Type C 1 nerve-sparing radical hysterectomy following definitive chemoradiation in advanced cervical cancer?
  3. What is the feasibility and safety of Type C1 nerve-sparing radical hysterectomy postdefinitive chemoradiation in advanced carcinoma cervix?

Doctor’s Tip

A helpful tip a doctor might tell a patient about radical hysterectomy is to follow all post-operative care instructions carefully, including taking prescribed medications, attending follow-up appointments, and avoiding heavy lifting or strenuous activity for a certain period of time. It is also important to communicate any unusual symptoms or concerns to your healthcare provider promptly.

Suitable For

Patients with advanced squamous cell carcinoma of the cervix who have undergone definitive concurrent chemoradiotherapy are typically recommended for Type C1 nerve-sparing radical hysterectomy. This approach is feasible and has shown minimal morbidity in postoperative outcomes. Patients with persistent residual disease after chemoradiation or those with node-positive disease may benefit from this surgical intervention. The study also suggests that the laparoscopic approach for radical hysterectomy may result in reduced bladder morbidity compared to open surgery.

Timeline

  • Before radical hysterectomy:
  1. Patient is diagnosed with advanced cervical cancer.
  2. Patient undergoes evaluation for treatment options, which may include chemotherapy and radiation therapy.
  3. Patient receives definitive concurrent chemoradiotherapy to shrink the tumor and eliminate cancer cells.
  4. Post-treatment evaluation shows persistent residual disease in some patients.
  5. Patient is assessed for surgery, specifically Type C 1 nerve-sparing radical hysterectomy.
  • After radical hysterectomy:
  1. Patient undergoes Type C 1 nerve-sparing radical hysterectomy either by open surgery or laparoscopic approach.
  2. Pathology results show either complete response to treatment or node-positive disease in some patients.
  3. Patients are monitored for postoperative morbidity, with minimal bladder morbidity reported in the laparoscopic group.
  4. One patient in the laparoscopic group experiences persistent vaginal discharge.
  5. Overall, Type C 1 nerve-sparing radical hysterectomy is found to be technically feasible with minimal morbidity following definitive chemoradiation in patients with advanced squamous cell carcinoma of the cervix.

What to Ask Your Doctor

  1. What are the potential risks and complications associated with a radical hysterectomy?
  2. How will a radical hysterectomy affect my fertility and sexual function?
  3. What is the likelihood of achieving a complete response to treatment with a radical hysterectomy?
  4. How long is the recovery period after a radical hysterectomy?
  5. Will I require any additional treatments or follow-up care after a radical hysterectomy?
  6. What is the success rate of Type C 1 nerve-sparing radical hysterectomy in patients with advanced cervical cancer?
  7. What are the differences in outcomes between open surgery and laparoscopic surgery for Type C 1 nerve-sparing radical hysterectomy?
  8. How will a radical hysterectomy impact my overall quality of life?
  9. Are there any alternative treatment options to consider instead of a radical hysterectomy?
  10. What are the long-term implications of undergoing a radical hysterectomy for advanced cervical cancer?

Reference

Authors: Sundaram GS, Kothari S, Voleti SK, Krishna V, Bose JC. Journal: J Cancer Res Ther. 2022 Oct-Dec;18(6):1559-1563. doi: 10.4103/jcrt.JCRT_557_20. PMID: 36412410