Our Summary

This study looked at whether MRI scans with targeted biopsy (taking a small sample of body tissue) are as effective as the more commonly used 12-core transrectal ultrasonography (TRUS) biopsy in diagnosing prostate cancer.

The study involved men who had a suspicion of having prostate cancer but had never had a biopsy before. They were split into two groups: one underwent an MRI scan and had a biopsy only if a certain type of lesion was identified; the other group underwent a TRUS biopsy.

The results showed that both methods were equally effective in identifying significant cancers. However, the MRI group had fewer side effects and less detection of low-grade cancers, which often don’t need treatment and can lead to unnecessary anxiety and intervention.

In simpler terms, this research found that an MRI scan followed by a targeted biopsy, if necessary, is just as good as the usual biopsy method in detecting serious cases of prostate cancer. Plus, it has the added benefits of fewer side effects and less over-diagnosis of harmless cancers.

FAQs

  1. What was the purpose of the study comparing MRI scans with targeted biopsy to the 12-core transrectal ultrasonography (TRUS) biopsy?
  2. How did the results of the study compare the effectiveness of MRI scans with targeted biopsy and TRUS biopsy in diagnosing prostate cancer?
  3. What are the potential benefits of using an MRI scan followed by a targeted biopsy for diagnosing prostate cancer, based on the study’s findings?

Doctor’s Tip

Therefore, a helpful tip a doctor might give a patient about prostate biopsy is to consider discussing the option of having an MRI scan first, especially if there is a suspicion of prostate cancer. This approach may lead to a more accurate diagnosis and potentially reduce the risk of unnecessary treatment for non-serious cases of prostate cancer. It’s important to have a thorough discussion with your healthcare provider about the best course of action for your individual situation.

Suitable For

Patients who are typically recommended for a prostate biopsy include those with elevated levels of prostate-specific antigen (PSA) in the blood, abnormal digital rectal exam findings, or a family history of prostate cancer. Additionally, patients with suspicious lesions detected on imaging studies such as MRI may also be recommended for a biopsy to confirm or rule out the presence of prostate cancer.

Timeline

Before the prostate biopsy:

  1. Patient consults with their healthcare provider about concerns or symptoms related to prostate cancer.
  2. Patient may undergo a digital rectal exam (DRE) and/or a prostate-specific antigen (PSA) blood test to determine if further testing is needed.
  3. If further testing is recommended, patient may undergo a MRI scan to identify suspicious areas in the prostate.
  4. If a lesion is identified on the MRI, patient may be scheduled for a targeted biopsy.

After the prostate biopsy:

  1. Patient is informed about the procedure and given instructions on how to prepare (e.g. fasting, medications to avoid).
  2. Biopsy is performed, typically under local anesthesia, by inserting a needle into the prostate to collect tissue samples.
  3. Patient may experience discomfort, bleeding, or other side effects immediately following the biopsy.
  4. Biopsy samples are sent to a lab for analysis to determine if cancer is present.
  5. Patient receives the biopsy results and discusses treatment options with their healthcare provider, if necessary.

What to Ask Your Doctor

  1. What are the potential risks and side effects of a prostate biopsy?

  2. How will the results of the biopsy affect my treatment options?

  3. Are there any alternative screening methods or tests that could be considered instead of a biopsy?

  4. How accurate is the MRI scan in detecting suspicious lesions in the prostate?

  5. How long will it take to receive the results of the biopsy?

  6. Will I need to undergo any special preparation or follow-up care after the biopsy?

  7. What is the likelihood of detecting significant prostate cancer with a targeted biopsy compared to a TRUS biopsy?

  8. Will the MRI scan and targeted biopsy be covered by my insurance?

  9. How experienced is the medical team in performing MRI-guided prostate biopsies?

  10. Are there any specific factors about my health or prostate that may impact the effectiveness of a biopsy?

Reference

Authors: Klotz L, Chin J, Black PC, Finelli A, Anidjar M, Bladou F, Mercado A, Levental M, Ghai S, Chang SD, Milot L, Patel C, Kassam Z, Moore C, Kasivisvanathan V, Loblaw A, Kebabdjian M, Earle CC, Pond GR, Haider MA. Journal: JAMA Oncol. 2021 Apr 1;7(4):534-542. doi: 10.1001/jamaoncol.2020.7589. PMID: 33538782