Our Summary

This research paper aimed to evaluate the use of a test for prostatitis (a type of prostate inflammation) to improve the reliability of the prostate specific antigen (PSA) test, which is often used to detect prostate cancer. This could help to avoid unnecessary prostate biopsies.

178 patients with higher than normal PSA levels and positive results for a prostatitis test were included in the study. Various diagnostic evaluations were conducted, including a prostate biopsy.

The study found that 36.9% of the men in the study had a particular type of prostatitis. In the group of patients with this prostatitis but no symptoms, a higher average level of white blood cells (leucocytes) was found in the prostate secretion compared to the other two groups.

The study also analyzed the relationship between the number of white blood cells in the prostate secretion and prostatitis, benign prostate hyperplasia (a non-cancerous enlargement of the prostate), and prostate cancer.

It was concluded that if the number of white blood cells was 16 or above, the sensitivity of the test was high. This means that the test is good at correctly identifying those with the condition. The researchers believe that this new cut-off value could aid in the decision to perform a biopsy when used alongside the PSA test.

FAQs

  1. What was the main aim of this research paper on prostate biopsy?
  2. What were the main findings of the study regarding the relationship between the number of white blood cells in the prostate secretion and prostatitis?
  3. How could the findings of this research potentially help in avoiding unnecessary prostate biopsies?

Doctor’s Tip

One helpful tip a doctor might tell a patient about prostate biopsy is to discuss the results of a prostatitis test alongside the PSA levels. This can help determine if a biopsy is necessary or if the elevated PSA levels could be due to inflammation rather than cancer. By considering all available information, including white blood cell counts in the prostate secretion, doctors can make a more informed decision about the need for a biopsy. It’s important to have open communication with your healthcare provider and ask any questions you may have about the testing process.

Suitable For

Patients who are typically recommended for a prostate biopsy include those with elevated PSA levels, positive prostatitis test results, and/or symptoms of prostatitis. Additionally, patients with a family history of prostate cancer, abnormal digital rectal exam findings, or other risk factors for prostate cancer may also be recommended for a biopsy. The findings from this study suggest that incorporating a prostatitis test and evaluating white blood cell levels in the prostate secretion could help improve the accuracy of the PSA test and aid in the decision-making process for performing a biopsy.

Timeline

Before the prostate biopsy:

  • Patient has higher than normal PSA levels
  • Positive results for a prostatitis test
  • Various diagnostic evaluations conducted
  • Study found 36.9% of patients had prostatitis
  • Analysis of white blood cell levels in prostate secretion

After the prostate biopsy:

  • Conclusion that high white blood cell count is indicative of prostatitis
  • New cut-off value identified to aid in decision to perform biopsy
  • Potential to improve reliability of PSA test
  • Potential to avoid unnecessary prostate biopsies

What to Ask Your Doctor

  1. What is the purpose of a prostate biopsy and why is it being recommended for me?
  2. What are the risks and potential complications associated with a prostate biopsy?
  3. How will the biopsy be performed and what can I expect during the procedure?
  4. Are there any alternative tests or procedures that could be considered instead of a biopsy?
  5. Will the results of the biopsy definitively diagnose prostate cancer or are there other factors to consider?
  6. How long will it take to receive the results of the biopsy and what will happen next based on those results?
  7. Are there any specific instructions or precautions I should follow before or after the biopsy?
  8. How often should I have follow-up screenings or tests after the biopsy, regardless of the results?
  9. Are there any lifestyle changes or treatments that could potentially reduce the risk of prostate cancer or other prostate conditions in the future?
  10. Are there any additional questions or concerns I should address before proceeding with the biopsy?

Reference

Authors: Ergun O, Capar E, Goger YE, Ergun AG. Journal: Int Braz J Urol. 2019 Mar-Apr;45(2):246-252. doi: 10.1590/S1677-5538.IBJU.2018.0292. PMID: 30648827