Our Summary

This research paper investigates the use of human amniotic membrane (HAM) in oral surgery. The amniotic membrane is a part of the placenta, which surrounds the fetus in the womb. It has unique properties that make it useful in various medical fields, and it does not raise ethical concerns because it is normally discarded after childbirth.

The researchers reviewed studies published between January 1985 and March 2024 and found that HAM can be preserved in different ways, such as fresh, decellularized, frozen, lyophilized (freeze-dried), and air-dried. The studies showed that HAM can be effective in repairing oral tissue damage, improving oral surgery procedures, closing gaps between the mouth and nose, treating cleft palate, repairing bone defects, and treating a condition called medication-related osteonecrosis of the jaw (a severe bone disease caused by medications).

Surgeons found HAM easy to handle, but noted some challenges in stitching it in place and keeping it stable during surgery. The researchers conclude that the amniotic membrane is a versatile and effective tool in oral surgery, as it helps wounds heal, reduces inflammation, and provides a scaffold for new tissue to grow. However, more research is needed to confirm its effectiveness and determine the best ways to use it in clinical practice.

FAQs

  1. What is the human amniotic membrane (HAM) and how is it used in maxillofacial surgery?
  2. What are the different preservation methods for HAM identified in the study?
  3. What are the benefits and challenges of using HAM in maxillofacial surgeries as highlighted in the surgeon evaluations?

Doctor’s Tip

A helpful tip a doctor might give a patient about maxillofacial surgery involving the use of amniotic membrane is to follow post-operative care instructions carefully to ensure proper healing and optimal outcomes. This may include instructions on wound care, pain management, dietary restrictions, and follow-up appointments. Additionally, it is important to report any unusual symptoms or complications to the healthcare provider promptly. By following these recommendations, patients can help facilitate the healing process and achieve the best possible results from their surgery.

Suitable For

Patients who may be recommended for maxillofacial surgery include those with oral mucosal defects, vestibuloplasty, oronasal fistulas, cleft palate, bone defects, and medication-related osteonecrosis of the jaw (MRONJ). These patients can benefit from the use of human amniotic membrane (HAM) in their surgical procedures, as it has been shown to promote wound healing, reduce inflammation, and provide a scaffold for tissue regeneration. Surgeons have noted the ease of handling HAM but may encounter challenges in suturing and stability during application. Further research, including randomized trials and comparative studies, is needed to validate the efficacy and optimize the utilization of HAM in maxillofacial surgery.

Timeline

  • Pre-surgery: The patient undergoes a consultation with a maxillofacial surgeon to discuss their condition and treatment options. They may undergo various tests and evaluations to determine the best course of action. The surgeon may recommend using amniotic membrane in the surgery based on the patient’s needs.

  • Day of surgery: The patient arrives at the hospital or surgical center and undergoes pre-operative preparations. The surgical team prepares the amniotic membrane for use during the procedure. The patient is administered anesthesia, and the surgery is performed according to the planned approach.

  • Post-surgery: The patient wakes up in the recovery room and is monitored closely for any complications. Pain medication and antibiotics may be prescribed to manage discomfort and prevent infection. The patient may experience swelling, bruising, and discomfort in the days following surgery. Follow-up appointments are scheduled to monitor healing and ensure the success of the procedure.

Overall, the use of amniotic membrane in maxillofacial surgery offers a promising approach to promoting wound healing and tissue regeneration, ultimately leading to improved outcomes for patients.

What to Ask Your Doctor

  1. What specific benefits can I expect from using amniotic membrane in my maxillofacial surgery procedure?
  2. How will the amniotic membrane be prepared and applied during the surgery?
  3. Are there any risks or potential complications associated with using amniotic membrane in maxillofacial surgery?
  4. How does the use of amniotic membrane compare to other traditional treatment options for my condition?
  5. What is the success rate of using amniotic membrane in maxillofacial surgery based on current research and clinical experience?
  6. How long can I expect the effects of the amniotic membrane to last after the surgery?
  7. Will I need any additional follow-up care or treatments after the surgery involving amniotic membrane?
  8. Are there any specific post-operative instructions or precautions I should be aware of regarding the use of amniotic membrane in my surgery?
  9. Can you provide me with more information or resources to learn about the use of amniotic membrane in maxillofacial surgery?
  10. Are there any ongoing clinical trials or research studies investigating the use of amniotic membrane in maxillofacial surgery that I may be eligible to participate in?

Reference

Authors: Dawiec G, Niemczyk W, Wiench R, Niemczyk S, Skaba D. Journal: Medicina (Kaunas). 2024 Apr 19;60(4):663. doi: 10.3390/medicina60040663. PMID: 38674309