Our Summary

This research paper looks at the use of two drugs, tranexamic acid and ε-aminocaproic acid, to reduce blood loss and the need for blood transfusions during plastic surgery. The researchers analyzed 33 previous studies involving over 1,800 patients to understand how these drugs are being used, their benefits, and any potential complications.

The review found that these drugs are commonly used in craniofacial (head, neck, and face) and orthognathic (jaw) surgeries, and are usually given via an IV. Some doctors also use a topical version of the drugs, which is similarly effective but doesn’t spread throughout the body as much. The drugs don’t seem to increase the risk of any negative side effects.

In addition to reducing blood loss, tranexamic acid may be particularly useful in cosmetic surgery and burn treatment because it can improve the surgical field visibility, minimize swelling and bruising, and potentially speed up recovery.

The researchers conclude that more studies are needed to figure out the best ways to use these drugs in different types of surgical procedures.

FAQs

  1. What are the benefits of using tranexamic acid and ε-aminocaproic acid in plastic surgery?
  2. Do these drugs increase the risk of any negative side effects during or after surgery?
  3. How can tranexamic acid potentially speed up recovery in cosmetic surgery and burn treatment?

Doctor’s Tip

A doctor might advise a patient undergoing jaw surgery to discuss the potential benefits of using tranexamic acid or ε-aminocaproic acid with their surgeon. These drugs have been shown to reduce blood loss during surgery, potentially leading to a faster recovery and decreased need for blood transfusions. It’s important for patients to have a thorough discussion with their healthcare provider about the risks and benefits of using these medications in their specific case.

Suitable For

Patients who may be recommended for jaw surgery include those with:

  1. Malocclusion (misalignment of the teeth and jaws)
  2. Facial asymmetry
  3. Difficulty chewing or speaking
  4. Temporomandibular joint (TMJ) disorders
  5. Sleep apnea
  6. Corrective jaw surgery for orthodontic purposes

It is important for patients to consult with a maxillofacial surgeon to determine if they are a suitable candidate for jaw surgery and to discuss the potential benefits and risks associated with the procedure.

Timeline

Before jaw surgery, a patient typically undergoes a consultation with a surgeon to discuss the procedure, potential risks, and expected outcomes. They may also need to undergo orthodontic treatment to prepare their teeth and jaw for surgery. The patient will also likely need to undergo pre-operative tests and evaluations to ensure they are healthy enough for surgery.

During jaw surgery, the patient will be under general anesthesia and the surgeon will make incisions inside the mouth to access the jawbone. The surgeon will then reposition the jawbone to correct any alignment issues before securing it in place with screws or plates. The incisions will be closed and the patient will be monitored as they wake up from anesthesia.

After jaw surgery, the patient will need to follow specific post-operative care instructions, which may include a liquid or soft food diet, pain management, and oral hygiene practices. The patient will also have follow-up appointments with the surgeon to monitor their healing progress and ensure that the jaw is properly aligned. Physical therapy may also be recommended to help with jaw function and mobility.

Overall, the recovery process from jaw surgery can vary depending on the individual and the extent of the surgery, but most patients can expect to return to normal activities within a few weeks to a few months.

What to Ask Your Doctor

  1. What are the potential benefits of using tranexamic acid or ε-aminocaproic acid during jaw surgery?
  2. Are there any potential complications or side effects associated with these drugs?
  3. How are these drugs typically administered during surgery?
  4. How do these drugs compare to other methods of reducing blood loss during surgery?
  5. Will the use of these drugs impact my recovery time or post-operative care?
  6. Are there any specific factors about my medical history or current medications that may impact the effectiveness of these drugs?
  7. Are there any additional precautions or considerations I should be aware of before undergoing jaw surgery with the use of these drugs?
  8. What is the current research or evidence supporting the use of tranexamic acid and ε-aminocaproic acid in jaw surgery?

Reference

Authors: Brown S, Yao A, Taub PJ. Journal: Plast Reconstr Surg. 2018 Jun;141(6):937e-949e. doi: 10.1097/PRS.0000000000004421. PMID: 29794717