Our Summary

This research paper is about a study focused on a new method to potentially reduce the risk of ovarian cancer in individuals with a high inherited risk. This new method, called salpingectomy with delayed oophorectomy, involves removing the fallopian tubes and later removing the ovaries. This is based on evidence that suggests certain types of ovarian cancer start in the fallopian tubes.

The goal of the study is to figure out if this method is just as effective as the current standard procedure, which involves removing both the fallopian tubes and ovaries at the same time. The researchers believe that delaying the removal of the ovaries until later could still provide the same reduced risk of ovarian cancer.

The study will include premenopausal individuals who carry certain gene variants associated with a high risk of ovarian cancer, and who have finished having children. The main goal of the study is to see how many cases of ovarian cancer occur by a certain age among these individuals.

The researchers plan to recruit 3000 participants for the study, and expect to have results by 2036. The study began in 2021 and is expected to finish recruiting participants by the end of 2026.

FAQs

  1. What is the new method being studied to potentially reduce the risk of ovarian cancer?
  2. Who are the intended participants for this study on salpingectomy with delayed oophorectomy?
  3. When can we expect the results of this study on a new method to reduce ovarian cancer risk?

Doctor’s Tip

A helpful tip that a doctor might tell a patient about salpingo-oophorectomy is to discuss the potential benefits and risks of the procedure, as well as alternative options. It is important for the patient to understand why the surgery is being recommended and what the potential outcomes may be. Additionally, the doctor may advise the patient to follow up with regular screenings and appointments to monitor their health after the procedure.

Suitable For

Patients who are typically recommended salpingo-oophorectomy are those who have a high inherited risk of ovarian cancer, particularly individuals who carry certain gene variants associated with a high risk of the disease. These patients are often premenopausal and have completed childbearing. The goal of the procedure is to reduce the risk of developing ovarian cancer in these high-risk individuals.

Timeline

Before salpingo-oophorectomy:

  • Patient is identified as having a high inherited risk of ovarian cancer, potentially through genetic testing
  • Patient undergoes counseling and discussions with healthcare providers about their options for risk-reducing surgery
  • Patient decides to participate in the study and is enrolled
  • Patient undergoes salpingectomy, removing the fallopian tubes
  • Patient is monitored for any side effects or complications from the surgery

After salpingo-oophorectomy:

  • Patient continues to be monitored and receives regular follow-up appointments with healthcare providers
  • Patient waits for a period of time before undergoing oophorectomy, the removal of the ovaries
  • Patient may experience menopausal symptoms and hormonal changes after the ovaries are removed
  • Patient continues to be monitored for any signs of ovarian cancer or other health concerns
  • Researchers track the number of cases of ovarian cancer that occur among the study participants
  • Results of the study are analyzed and conclusions are made about the effectiveness of the new method for reducing the risk of ovarian cancer.

What to Ask Your Doctor

  1. What are the potential benefits of salpingectomy with delayed oophorectomy compared to the standard procedure of removing both the fallopian tubes and ovaries at the same time?

  2. What are the potential risks or complications associated with salpingectomy with delayed oophorectomy?

  3. How long is the recommended waiting period between the removal of the fallopian tubes and the removal of the ovaries in this new procedure?

  4. How will the removal of the fallopian tubes affect my fertility and hormone levels?

  5. How will this procedure impact my risk of developing ovarian cancer in the future?

  6. What are the criteria for being eligible to participate in this study?

  7. What will be expected of me as a participant in this study?

  8. What follow-up care will be provided after the procedure?

  9. How will the results of this study be communicated and how will they potentially impact future treatment options for individuals at high risk of ovarian cancer?

  10. Are there any alternative treatment options or considerations I should be aware of before making a decision about undergoing this procedure?

Reference

Authors: Steenbeek MP, van Bommel MHD, intHout J, Peterson CB, Simons M, Roes KCB, Kets M, Norquist BM, Swisher EM, Hermens RPMG; TUBA-WISP II consortium; Lu KH, de Hullu JA. Journal: Int J Gynecol Cancer. 2023 Jun 5;33(6):982-987. doi: 10.1136/ijgc-2023-004377. PMID: 37045546