Our Summary

This research paper studies the risk of infections in children with a blood disorder called hereditary spherocytosis (HS) before and after they have their spleen removed (a procedure called splenectomy). The study found that these children are more likely to be hospitalized due to infections before they have their spleen removed, compared to after the surgery. This is in contrast to the belief that removing the spleen increases the risk of severe infections. The study also found that these children are more likely to get infections than children who had their appendix removed. However, after the spleen is removed, this risk decreases. The paper suggests that with the right use of vaccines or antibiotics after surgery, the benefits of removing the spleen in children with severe HS could outweigh the risks.

FAQs

  1. Does the removal of the spleen increase the risk of severe infections in children with hereditary spherocytosis (HS)?
  2. Are children with HS more likely to get infections before or after the splenectomy procedure?
  3. How does the infection risk in children with HS who have undergone a splenectomy compare to children who have had their appendix removed?

Doctor’s Tip

One helpful tip a doctor might tell a patient about splenectomy is to stay up to date on vaccinations, especially those that protect against infections such as pneumonia and meningitis. It is also important to be vigilant about practicing good hygiene and avoiding contact with sick individuals to reduce the risk of infections after splenectomy. Additionally, patients should promptly seek medical attention if they develop any signs of infection, such as fever, chills, or unusual tiredness, as these can be more serious in individuals without a spleen.

Suitable For

Patients who are typically recommended splenectomy include those with hereditary spherocytosis (HS) who experience severe complications such as anemia, jaundice, gallstones, and frequent infections. Splenectomy may also be recommended for patients with other blood disorders such as thalassemia, sickle cell disease, and autoimmune hemolytic anemia. Additionally, patients with trauma or tumors affecting the spleen may also require splenectomy. Ultimately, the decision to undergo splenectomy is based on the individual patient’s medical history, symptoms, and overall health condition.

Timeline

  • Before splenectomy:
  1. Patient is diagnosed with hereditary spherocytosis (HS) and experiences symptoms such as anemia, jaundice, and fatigue.
  2. Patient may have frequent infections due to the spleen not functioning properly.
  3. Patient may require hospitalization for severe infections.
  4. Patient and healthcare team discuss the option of splenectomy as a treatment for HS.
  • After splenectomy:
  1. Patient undergoes splenectomy surgery to remove the spleen.
  2. Patient may experience a period of recovery post-surgery.
  3. Patient is at higher risk of infections immediately after surgery due to the absence of the spleen.
  4. Patient receives vaccinations and antibiotics to prevent infections.
  5. Over time, the risk of infections decreases as the body adapts to the absence of the spleen and the immune system compensates for its functions.
  6. Patient may experience improved quality of life, with fewer infections and symptoms of HS.

What to Ask Your Doctor

  1. What are the potential risks and benefits of splenectomy for my specific condition?
  2. How will removing my spleen affect my risk of infections, both before and after surgery?
  3. What vaccines or antibiotics will I need to take after the surgery to prevent infections?
  4. How will my immune system be affected by the loss of my spleen, and what steps can I take to protect my health?
  5. Are there any alternative treatments or management strategies for my condition that do not involve splenectomy?
  6. What is the recovery process like after splenectomy, and what precautions should I take to avoid complications?
  7. How often will I need to follow up with you after the surgery to monitor my health and any potential complications?
  8. Are there any long-term consequences or risks associated with living without a spleen?
  9. How will my quality of life be affected by the surgery, and what support resources are available to help me adjust?
  10. Are there any specific lifestyle changes or precautions I should take after splenectomy to stay healthy and prevent infections?

Reference

Authors: Liu Y, Jin S, Xu R, Ding C, Pang W, Li Y, Chen Y. Journal: Pediatr Res. 2023 Apr;93(5):1336-1341. doi: 10.1038/s41390-022-02229-y. Epub 2022 Aug 1. PMID: 35915237