Our Summary

This research was conducted to see if removing the spleen (splenectomy) would reduce the immune system’s response to brain damage after a stroke, and thus improve the patient’s condition. The experiment involved inducing a stroke in male rats immediately after either a real or a fake (sham) splenectomy. The rats were then observed for 4 weeks, and the immune response to a specific brain protein was measured. The size of the brain damage was also measured in some of the rats after 72 hours. The researchers found that removing the spleen did not reduce the immune response or improve the rats’ conditions. The rats who had their spleens removed did show worse neurological scores immediately after the stroke, but the size of the brain damage and their behavior was the same as the rats who had not had their spleens removed. This suggests that the spleen does not play a significant role in the immune response to a stroke.

FAQs

  1. Does splenectomy alter the immune responses to brain antigens after a stroke?
  2. Does a splenectomy improve the outcome after a stroke?
  3. Does a splenectomy have an impact on infarct size or behavioral outcomes after a stroke?

Doctor’s Tip

A helpful tip a doctor might tell a patient about splenectomy is to be aware that the procedure may not necessarily improve outcomes after a stroke. It is important to discuss all potential risks and benefits with your healthcare provider before undergoing the surgery. Additionally, post-operative care and follow-up appointments are crucial for monitoring recovery and overall health.

Suitable For

Patients who may be recommended for splenectomy include those with certain blood disorders such as hereditary spherocytosis, thalassemia, and immune thrombocytopenia. Splenectomy may also be recommended for patients with certain types of cancer, such as Hodgkin’s lymphoma or splenic tumors. Additionally, patients with certain infections or conditions that affect the spleen, such as sickle cell disease or autoimmune diseases, may also be candidates for splenectomy.

Timeline

Before splenectomy:

  1. The patient undergoes medical evaluation and diagnostic tests to determine the need for splenectomy.
  2. The patient and medical team discuss the risks and benefits of the procedure.
  3. Preoperative preparations are made, including fasting before surgery and stopping certain medications.
  4. The patient undergoes splenectomy surgery, which can be done laparoscopically or through open surgery.

After splenectomy:

  1. The patient is monitored closely in the hospital for any complications or side effects of the surgery.
  2. The patient may experience pain, fatigue, and discomfort in the abdomen.
  3. The patient may be prescribed antibiotics to prevent infections, as the spleen is an important part of the immune system.
  4. The patient may need to receive vaccinations against certain infections, as the spleen plays a role in fighting off bacteria.
  5. Over time, the patient’s body adjusts to the absence of the spleen, and they may be able to resume normal activities.
  6. The patient may be at increased risk for certain infections, and will need to be vigilant about monitoring for signs of infection and seeking prompt medical treatment if necessary.

What to Ask Your Doctor

Some questions a patient should ask their doctor about splenectomy include:

  1. What are the potential risks and complications associated with a splenectomy?
  2. How will my immune system be affected after the spleen is removed?
  3. Will I need any vaccinations or medications to help prevent infections after the surgery?
  4. How long is the recovery period after a splenectomy?
  5. Will I need to make any lifestyle changes or adjustments after the surgery?
  6. How will a splenectomy impact my overall health and well-being in the long term?
  7. Are there any alternative treatments or therapies that could be considered instead of a splenectomy?
  8. How will a splenectomy affect my risk of developing certain diseases or conditions in the future?
  9. What should I do if I experience any symptoms or complications after the surgery?
  10. Will I need to follow up with a specialist or have any additional tests or procedures done after the splenectomy?

Reference

Authors: Zierath D, Shen A, Stults A, Olmstead T, Becker KJ. Journal: Stroke. 2017 Feb;48(2):497-500. doi: 10.1161/STROKEAHA.116.016037. Epub 2017 Jan 13. PMID: 28087806