Our Summary

This paper discusses a hormone called glucagon-like peptide-2 (GLP-2) which is produced in the intestines and helps with things like digestion, nutrient absorption, and maintaining the health and function of the intestines. This hormone is especially beneficial for individuals with intestinal failure. Scientists have recently developed a medication based on GLP-2 that can be used to treat patients with short bowel syndrome, a condition where the intestines are not long enough to properly absorb nutrients. The researchers review everything we know about GLP-2, including how it is produced and how it works in the body. They also discuss its benefits for people with intestinal diseases and short bowel syndrome. The paper highlights the successful transition from scientific discovery to practical treatment.

FAQs

  1. What is the glucagon-like peptide-2 (GLP-2) hormone and what is its function in the body?
  2. How can the GLP-2 based medication benefit patients with short bowel syndrome?
  3. How has the understanding of GLP-2 transitioned from scientific discovery to practical treatment?

Doctor’s Tip

A doctor may tell a patient about the importance of maintaining a healthy diet and lifestyle after intestinal resection. They may recommend eating smaller, more frequent meals, staying hydrated, and avoiding foods that may cause discomfort or irritation to the intestines. They may also advise the patient to take any prescribed medications as directed and to follow up with regular appointments to monitor their progress and overall health. It is important for patients to communicate any concerns or changes in symptoms to their healthcare provider to ensure they are receiving the proper care and support.

Suitable For

Patients who are typically recommended intestinal resection include those with:

  1. Intestinal cancer
  2. Intestinal obstruction
  3. Crohn’s disease
  4. Ulcerative colitis
  5. Diverticulitis
  6. Intestinal ischemia

These conditions may require surgical removal of a portion of the intestine in order to treat the underlying issue and improve the patient’s overall health and quality of life.

Timeline

Before intestinal resection:

  1. Patient undergoes tests and evaluations to determine the need for intestinal resection.
  2. Surgery is scheduled and patient receives pre-operative instructions.
  3. Patient undergoes intestinal resection surgery to remove a portion of the intestines.
  4. Patient is monitored closely in the hospital post-surgery for complications.

After intestinal resection:

  1. Patient may experience pain, discomfort, and fatigue post-surgery.
  2. Patient is placed on a liquid diet initially and gradually progresses to solid foods.
  3. Patient may require medications for pain management and to prevent infections.
  4. Patient undergoes follow-up appointments with healthcare providers to monitor healing and recovery.
  5. Patient may require dietary modifications and nutritional support to compensate for the decreased absorption capacity of the intestines.
  6. Patient may experience changes in bowel habits and digestion.
  7. Patient may require ongoing monitoring and management of any complications or deficiencies that arise post-surgery.

What to Ask Your Doctor

  1. What is an intestinal resection and why is it necessary for my condition?
  2. What are the potential risks and complications of having an intestinal resection?
  3. How will an intestinal resection affect my digestion and nutrient absorption?
  4. Will I need to make any dietary or lifestyle changes after the procedure?
  5. How long is the recovery process after an intestinal resection and what can I expect during this time?
  6. Are there any long-term effects or complications I should be aware of after having an intestinal resection?
  7. Will I need any additional treatments or medications to support my digestive health after the procedure?
  8. How often will I need follow-up appointments or tests to monitor my intestinal health post-resection?
  9. Are there any support groups or resources available for individuals who have undergone an intestinal resection?
  10. Are there any alternative treatments or therapies that may be beneficial for me in conjunction with or instead of an intestinal resection?

Reference

Authors: Brubaker PL. Journal: Compr Physiol. 2018 Jun 18;8(3):1185-1210. doi: 10.1002/cphy.c170055. PMID: 29978894