Our Summary

The research paper discusses the effect of a new drug, FE 203799 (also known as apraglutide), on the growth and adaptation of the intestines in newborn piglets with short bowel syndrome (SBS). This syndrome is often seen in newborns when a part of the intestine known as the ileum is removed or doesn’t function properly, leading to reduced absorption of nutrients.

The scientists randomized piglets into two groups - one group was given saline (a control group) and the other was given the drug. The piglets had 75% of their intestines surgically removed, and then were fed both intravenously and orally. The saline and the drug were injected under the skin on the first and fourth days of the experiment.

On the seventh day, they found that both groups of piglets were healthy and had gained a similar amount of weight. However, the piglets treated with the drug had less fat and energy loss in their feces, suggesting better absorption of nutrients. They also had longer and heavier small intestines, and their intestines showed signs of better adaptation to the loss of the ileum.

These results suggest that this drug could be useful in treating newborns with SBS. If the intestines can grow and adapt better, the baby could potentially be weaned off intravenous feeding more quickly.

FAQs

  1. What is the new drug FE 203799 (apraglutide) being researched for?
  2. How does the drug FE 203799 (apraglutide) affect piglets with short bowel syndrome in the study?
  3. Based on the study, how could the drug FE 203799 (apraglutide) potentially benefit newborns with short bowel syndrome?

Doctor’s Tip

A helpful tip a doctor might tell a patient about intestinal resection is to follow a healthy diet rich in fiber, protein, and nutrients to support healing and promote good bowel function. It is also important to stay hydrated and avoid foods that may cause digestive issues or discomfort. Regular exercise can also help improve bowel motility and overall health. Additionally, it is important to follow any post-operative instructions provided by your healthcare team and attend follow-up appointments to monitor your recovery progress.

Suitable For

Patients who are typically recommended intestinal resection include those with:

  1. Short bowel syndrome (SBS) - where a portion of the small intestine is removed or not functioning properly, leading to malabsorption of nutrients
  2. Intestinal obstruction - where there is a blockage in the intestines that cannot be resolved with other treatments
  3. Crohn’s disease - a chronic inflammatory condition that can cause damage to the intestines, leading to the need for surgical resection
  4. Intestinal cancer - where a portion of the intestine may need to be removed to treat the cancer
  5. Diverticulitis - inflammation or infection of small pouches that can form in the intestines, which may require surgical removal of the affected portion

Overall, patients who are experiencing complications or serious conditions affecting their intestines may be recommended for intestinal resection to improve their health and quality of life.

Timeline

Before intestinal resection:

  1. Patient is diagnosed with a condition that requires surgical removal of a portion of the intestine.
  2. Patient undergoes pre-operative evaluation and preparation for the surgery.
  3. Surgery is performed to remove the affected portion of the intestine.
  4. Patient may experience post-operative complications such as infection, bleeding, or bowel obstruction.
  5. Patient is put on a restricted diet and may require intravenous nutrition to support healing and recovery.

After intestinal resection:

  1. Patient undergoes a period of recovery in the hospital, closely monitored for any complications.
  2. Patient gradually resumes eating solid foods and may require dietary adjustments to account for reduced intestinal function.
  3. Patient may experience changes in bowel habits, such as diarrhea or constipation.
  4. Over time, patient’s remaining intestine may adapt and compensate for the lost portion.
  5. Patient may require ongoing medical management and monitoring to ensure proper absorption of nutrients and overall health.

What to Ask Your Doctor

Some questions a patient should ask their doctor about intestinal resection include:

  1. What is the reason for the intestinal resection surgery?
  2. What are the potential risks and complications associated with intestinal resection?
  3. How long will the recovery process be following the surgery?
  4. Will I need to make any dietary or lifestyle changes after the surgery?
  5. What are the long-term effects of intestinal resection on my digestive health?
  6. Will I need any additional treatments or medications after the surgery?
  7. How often will I need follow-up appointments to monitor my progress?
  8. Are there any alternative treatments or procedures that could be considered instead of intestinal resection?
  9. How will intestinal resection affect my ability to absorb nutrients from food?
  10. Will I need any additional support or resources to help with the recovery process?

Reference

Authors: Slim GM, Lansing M, Wizzard P, Nation PN, Wheeler SE, Brubaker PL, Jeppesen PB, Wales PW, Turner JM. Journal: JPEN J Parenter Enteral Nutr. 2019 Sep;43(7):891-898. doi: 10.1002/jpen.1500. Epub 2019 Jan 6. PMID: 30614011