Our Summary

This research paper is about a disease called Polypous rhinosinusitis (PRS), a difficult to treat condition characterized by inflammation and the growth of polyps in the nasal and sinus cavities. This disease often comes back after treatment, and its cause is still unknown. The standard treatment focuses on surgically removing the polyps and reducing inflammation, but doesn’t pay enough attention to other factors that could be contributing to the disease, like oxidative stress and a dysfunction in the mucociliary system (which helps to clear mucus and bacteria from our airways).

The researchers wanted to find a better way to treat PRS. They studied 98 patients, half of whom made up the study group and the other half the control group. Both groups received the standard combined treatment (surgery and a nasal spray), but the study group was also given a drug called N-acetylcysteine.

The patients’ progress was tracked using a range of methods, including questionnaires, endoscopy, CT scans and a saccharin test to evaluate the function of the mucociliary system. The researchers compared the results before surgery and after 6, 12, and 24 months.

They found that patients who took N-acetylcysteine had a more noticeable and long-lasting improvement in their overall condition compared to the control group. They also had fewer relapses and more successful surgical outcomes.

In conclusion, using N-acetylcysteine as part of the treatment for PRS can improve the effectiveness of surgery, reduce the number of relapses, and improve the patient’s overall condition.

FAQs

  1. What is Polypous rhinosinusitis (PRS) and what are the usual treatments?
  2. What was the purpose of the research study on PRS and N-acetylcysteine?
  3. What were the findings of the research study on the use of N-acetylcysteine in treating PRS?

Doctor’s Tip

A helpful tip a doctor might give a patient about nasal polyp removal is to consider incorporating N-acetylcysteine into their treatment plan to potentially enhance the effectiveness of the surgery, reduce the likelihood of relapses, and improve their overall condition. It is important to discuss this option with your healthcare provider to see if it is suitable for your individual case.

Suitable For

Patients who are recommended nasal polyp removal typically have Polypous rhinosinusitis (PRS) or chronic rhinosinusitis with nasal polyps. These patients often experience symptoms such as nasal congestion, loss of smell, facial pressure, and postnasal drip. They may have tried other treatments such as nasal sprays, antibiotics, and corticosteroids without success.

Additionally, patients who have recurrent nasal polyps despite previous surgical removal may also be recommended for nasal polyp removal. These patients may have more severe symptoms and a higher likelihood of complications if left untreated.

It is important for patients to consult with an ENT specialist to determine if nasal polyp removal is the best course of action for their condition. The decision to undergo surgery should be based on the severity of symptoms, response to previous treatments, and overall health of the patient.

Timeline

Timeline:

  • Before nasal polyp removal:
  1. Patient experiences symptoms such as nasal congestion, runny nose, facial pain, and decreased sense of smell.
  2. Patient may undergo diagnostic tests such as nasal endoscopy and CT scans to confirm the presence of nasal polyps.
  3. Patient may be prescribed medication such as nasal sprays or oral steroids to reduce inflammation and symptoms.
  • After nasal polyp removal:
  1. Patient undergoes surgery to remove the nasal polyps.
  2. Patient may experience some discomfort and nasal congestion immediately after surgery.
  3. Patient is prescribed medication to prevent infection and reduce inflammation post-surgery.
  4. Patient may undergo follow-up visits with their healthcare provider to monitor their recovery and assess the effectiveness of the surgery.
  5. Patient may start using N-acetylcysteine as part of their treatment regimen to improve outcomes and reduce the risk of relapse.
  6. Over time, patient experiences improved symptoms, better nasal airflow, and a reduced risk of polyp recurrence.

What to Ask Your Doctor

Some questions a patient should ask their doctor about nasal polyp removal include:

  1. What are the risks and benefits of nasal polyp removal surgery?
  2. How long will the recovery period be after the surgery?
  3. Will I need to take any medications or follow any specific post-operative care instructions?
  4. Are there any alternative treatments or medications that could be beneficial for my condition?
  5. How likely is it that the polyps will come back after surgery?
  6. Will I need to have regular follow-up appointments after the surgery?
  7. What can I do to prevent the recurrence of nasal polyps in the future?
  8. Are there any lifestyle changes or dietary modifications that could help improve my condition?
  9. What are the potential complications or side effects of the surgery?
  10. How long will it take for me to notice improvements in my symptoms after the surgery?

Reference

Authors: Popov IB, Shcherbakov DA, Tyryk OB, Aleksanyan TA. Journal: Vestn Otorinolaringol. 2020;85(3):48-51. doi: 10.17116/otorino20208503148. PMID: 32628383