Our Summary

This study looks at whether applying a drug called mitomycin-C (MMC) can help prevent the return of a type of nasal polyp after it has been removed. The researchers divided the patients into two groups. In one group, after the polyp was removed, MMC was applied to the area where the polyp was believed to have originated. The other group did not receive any MMC. The results showed that in the group that received the MMC, the polyps did not return. However, in the group that did not receive MMC, the polyps returned in 20% of the patients. The researchers concluded that applying MMC after removing the polyp is safe, easy, and effective at preventing the polyp from returning.

FAQs

  1. What is the purpose of applying mitomycin-C (MMC) after nasal polyp removal?
  2. How effective was MMC in preventing the return of nasal polyps according to the study?
  3. Is the application of MMC considered safe and easy after nasal polyp removal?

Doctor’s Tip

One helpful tip a doctor might tell a patient about nasal polyp removal is to discuss the option of applying a drug like mitomycin-C (MMC) after the procedure to help prevent the polyps from returning. This additional step may increase the success rate of the treatment and reduce the likelihood of needing further surgeries in the future. It is important to follow your doctor’s recommendations and attend follow-up appointments to monitor the effectiveness of the treatment.

Suitable For

Patients who are typically recommended nasal polyp removal are those who have chronic nasal congestion, difficulty breathing through the nose, frequent sinus infections, loss of sense of smell, and facial pain or pressure. These patients may have tried other treatments such as nasal sprays or medications without success. In some cases, nasal polyps can also cause snoring or sleep apnea, which can significantly impact quality of life. In these cases, surgical removal of the polyps may be recommended to improve symptoms and prevent complications.

Timeline

Before nasal polyp removal:

  • Patient may experience symptoms such as nasal congestion, loss of smell, facial pain or pressure, runny nose, and postnasal drip.
  • Patient may undergo a physical examination, nasal endoscopy, and imaging tests such as CT scans or MRI to diagnose the nasal polyps.
  • Patient may be prescribed medications such as corticosteroids, antihistamines, or decongestants to manage symptoms.

After nasal polyp removal:

  • Patient undergoes surgical removal of the nasal polyps, either through endoscopic sinus surgery or traditional open surgery.
  • In some cases, the surgeon may apply MMC to the area where the polyp originated to prevent recurrence.
  • Patient may experience mild pain, nasal congestion, and nasal drainage after the surgery.
  • Patient is advised to follow post-operative care instructions, including avoiding strenuous activities, using nasal saline rinses, and attending follow-up appointments.
  • Patient may experience improved symptoms such as better nasal breathing, improved sense of smell, and reduced facial pain or pressure.

What to Ask Your Doctor

  1. What are the risks and benefits of nasal polyp removal using MMC?
  2. How long does the procedure take and what is the recovery time?
  3. Will I need to stay in the hospital overnight or is it done as an outpatient procedure?
  4. Are there any alternative treatments or medications available for nasal polyps?
  5. How likely is it that the nasal polyps will return after removal with MMC?
  6. What can I expect in terms of post-operative pain and discomfort?
  7. Will I need to follow any specific post-operative care instructions or take any medications?
  8. How often will I need to follow up with you after the procedure?
  9. Are there any specific lifestyle changes or precautions I should take to prevent the recurrence of nasal polyps?
  10. Are there any long-term effects or complications associated with nasal polyp removal using MMC?

Reference

Authors: El-Anwar MW, Elmalt A, Annany A, Ahmed WA, Nofal AAF. Journal: Laryngoscope Investig Otolaryngol. 2021 Jun 28;6(4):619-622. doi: 10.1002/lio2.598. eCollection 2021 Aug. PMID: 34401480