Our Summary
This study explores the role of a protein called fibulin-5 in the occurrence of rectal prolapse, a condition where the last part of the intestine slips outside the anus. Previous studies have shown that fibulin-5, which helps maintain the structure of connective tissue, is important for preventing rectal prolapse in genetically modified mice.
In this research, skin samples were collected from 20 patients with rectal prolapse and 21 patients without the condition. These samples were used to grow fibroblasts, a type of cell that produces collagen and other proteins. The researchers measured the amount of fibulin-5 in these cells.
The results show that fibulin-5 levels were significantly lower in young male patients with rectal prolapse compared to those without the condition. However, there was no significant difference in fibulin-5 levels between women with and without rectal prolapse.
This suggests that fibulin-5 might be involved in causing rectal prolapse in a specific group of patients: young men. However, more research is needed to confirm this finding and understand why this protein doesn’t seem to affect rectal prolapse in women.
FAQs
- What is the role of fibulin-5 in the occurrence of rectal prolapse?
- Is there a difference in fibulin-5 levels between men and women with rectal prolapse?
- Why might fibulin-5 not affect rectal prolapse in women?
Doctor’s Tip
In terms of surgery for rectal prolapse, a doctor might advise the patient on the potential risks and benefits of the procedure, as well as the expected recovery time and post-operative care. They may also recommend certain lifestyle changes, such as maintaining a healthy diet high in fiber and staying hydrated, to help prevent future occurrences of rectal prolapse. It is important for the patient to follow their doctor’s instructions closely and attend all follow-up appointments to ensure a successful outcome.
Suitable For
Rectal prolapse surgery is typically recommended for patients who have tried conservative treatments such as dietary changes, pelvic floor exercises, and medications with no improvement in their symptoms. Patients who experience severe symptoms such as chronic constipation, fecal incontinence, and significant prolapse of the rectum may also be recommended for surgery.
Additionally, patients who have a large rectal prolapse that is causing significant discomfort, pain, or interference with daily activities may also be considered for surgery. It is important for patients to discuss their symptoms and treatment options with their healthcare provider to determine if rectal prolapse surgery is the best course of action for their individual case.
Timeline
Before rectal prolapse surgery, a patient may experience symptoms such as difficulty controlling bowel movements, a feeling of fullness or pressure in the rectum, and protrusion of tissue from the anus. The patient may undergo diagnostic tests such as a physical exam, colonoscopy, or imaging studies to confirm the diagnosis of rectal prolapse.
After surgery, the patient will typically experience some pain and discomfort in the rectal area, which can be managed with pain medication. The patient will need to follow a special diet to prevent constipation and avoid straining during bowel movements. It may take several weeks for the patient to fully recover from the surgery, and they will need to follow up with their healthcare provider for monitoring and follow-up care. With proper treatment and care, most patients can expect to have a good outcome and improved quality of life following rectal prolapse surgery.
What to Ask Your Doctor
Some questions a patient should ask their doctor about rectal prolapse surgery include:
- What is the success rate of rectal prolapse surgery?
- What are the potential risks and complications associated with the surgery?
- How long is the recovery period after rectal prolapse surgery?
- Will I need to make any lifestyle changes or follow a special diet after the surgery?
- Are there any alternative treatments or non-surgical options available for rectal prolapse?
- How long will I need to stay in the hospital after the surgery?
- What type of anesthesia will be used during the surgery?
- Will I need to undergo any additional tests or procedures before the surgery?
- How experienced are you in performing rectal prolapse surgery?
- What can I expect in terms of long-term outcomes and potential recurrence of rectal prolapse after the surgery?
Reference
Authors: Joshi HM, Gosselink MP, Smyth EA, Hompes R, Cunningham C, Lindsey I, Urban J, Jones OM. Journal: Colorectal Dis. 2015 Nov;17(11):996-1001. doi: 10.1111/codi.12972. PMID: 25891043